Genetics Referrals
The West of Scotland Cancer Genetics service is based to QEUH, Glasgow. Please send all referrals to:
West of Scotland Cancer Genetics Service
Department of Clinical Genetics
Level 2A, Laboratory Medicine
Queen Elizabeth University Hospital
1345 Govan Road
Glasgow G51 4TF
Phone 0141 354 9201 (reception)
When making a referral, please include as much information as possible about the:
- Type of cancer
- Relationship of any affected relative(s); especially those previously seen in the genetics clinic
- Name(s) of the affected relative(s); especially those previously seen in the genetics clinic
- Age(s) at diagnosis of the affected relative(s)
- Family History Questionnaire
In most families, a genetic test for cancer predisposition will not be available unless a gene alteration has already been identified in an affected relative. If this has been identified, please include in your referral the name and date of birth of the affected relative. If this has been identified, please include in your referral the name and date of birth of the affected relative, and which genetic centre was involved in identifying the gene so that we can access the relevant information in order to offer a test to your patient In other families, we usually need to test an affected relative first.
For breast cancer, the majorit of families will not have an alteration in the known genes BRCA1 and BRCA2m and testing will not be available to relatives.
Families eligible for testing include an individual with breast cancer under 40, 3 breast cancers under 50, 4 breast cancers under 60, or individuals with triple negative breast cancer under 60 or high grade serous ovarian cancer at any age.
Cancer risk (*see notes regarding first degree relatives)
Breast cancer | Low Risk | Moderate risk | High risk |
---|---|---|---|
1 Relative: | |||
Over 40 years at time of diagnosis | Reassure | ||
Under 40 years at time of diagnosis * | Refer | ||
With bilateral breast cancer * | Refer | ||
Male breast cancer * | Refer | ||
With both breast and ovarian cancer (double primary | Refer | ||
2 Relatives: | |||
2 relatives over 60 years | Reassure | ||
2 relatives under 60 years | Refer | ||
1 under 60 years and 1 relative with ovarian cancer | Refer | ||
1 relative under 40 years and 1 relative with childhood cancer | Refer | ||
3 Relatives: | |||
Any age * | Refer | ||
4 or more relatives | |||
under 60 years | Refer |
Ovarian Cancer | Low Risk | Moderate Risk | High Reisk |
---|---|---|---|
1 Relative: | |||
Any age | Reassure | ||
2 Relatives: | |||
or more with ovarian cancer* | Refer | ||
1 relative with ovarian cancer (any age) and 1 relative with breast cancer under 50 years* | Refer | ||
3 Relatives: | |||
1 relative with ovarian cancer (any age) AND 2 relatives with breast cancer under 60 years* | Refer | ||
4 Relatives: | |||
3 with colerectal cancer (1 under 50 years) AND 1 relative with ovarian cancer | Refer |
Colorectal Cancer | Low Risk | Moderate Risk | High Risk |
---|---|---|---|
1 Relative: | |||
Over 50 years | Reassure | ||
Under 50 years* | Refer | ||
2 Relatives: | |||
with average age under 60 years * OR TWO first degree relatives of any age | Refer | ||
3 or more Relatives | |||
All over 50 years * | Refer | ||
with 1 diagnosed under 50 years* | Refer |
* One relative must be a first degree relative unless through and intervening male AND all on the same side of the family
1st Degree = mother, sister, daughter, father, brother, son
2nd Degree = grandmother, grandaughter, aunt, neice, grandfather, grandson, uncle, nephew